2017-10-01

CONCLUSIONS: Early in the course of diabetic retinopathy, the function of the glutamate transporter in Müller cells is decreased by a mechanism that is likely to involve oxidation. PMID: 12202536 [Indexed for MEDLINE] Publication Types: Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. MeSH terms

47, no. 3, pp. 445–449, 1998. View at: Publisher Site | Google Scholar E. Rungger-Brändle, A. A. Dosso, and P. M. Leuenberger, “Glial reactivity, an early feature of diabetic retinopathy,” Investigative Ophthalmology & Visual Science , vol. 41, no. 7, pp. 1971–1980, 2000.

[Article in Russian] Nevroev VV, Zueva MV, Tsapenko IV, Riabina MV, Hun L. Electroretinographic examinations were made in 191 patients with non-proliferative and pre-proliferative diabetic retinopathy. High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy Findings indicate that HG-induced mitochondrial morphology changes and subsequent mitochondrial dysfunction may contribute to retinal Müller cell loss associated with diabetic retinopathy. Vascular cells may not be the only cells affected by diabetes in the retina. In particular, abnormalities of the b-wave of the electroretinogram in diabetic patients with absent or minimal microangiopathy have pointed to possible dysfunction of Müller cells, the principal glia of the retina.

1. Introduction. Diabetic retinopathy (DR) is the first cause of visual impairment and blindness in the adult working-age population [].For a long period of time, DR has been considered primarily a retinal microvascular disorder caused by the direct effects of hyperglycemia and by the metabolic pathways it activates [].

doi: 10.1038/cddis.2017.190. Diabetic retinopathy is the leading cause of blindness in the working-age population in Western countries [].The early stages of this devastating disease are characterized by high-glucose (HG)-mediated microvascular changes [2,3,4] as well as glial changes [5,6,7,8,9] in the retina, leading to loss of retinal endothelial cells, pericytes, and Müller glial cells. ORIGINAL ARTICLE VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy Murilo Rodrigues,1 Xiaoban Xin,1 Kathleen Jee,1 Savalan Babapoor-Farrokhran,1 Fabiana Kashiwabuchi,1 Tao Ma,2,3,4 Imran Bhutto,1 Syed Junaid Hassan,1 Yassine Daoud,1 David Baranano,1 Sharon Solomon,1 PURPOSE. To evaluate Müller cells as a potential source of fibrocontractive cells in proliferative diabetic retinopathy.

Müller cells and diabetic retinopathy. Müller cells are one of the primary glial cell types found in the retina and play a significant role in maintaining retinal function and health. Since Müller cells are the only cell type to span the entire width of the retina and have contact to almost every cell type in the retina they are uniquely ….

The study concludes that diabetes triggers retinal neuroinﬂammation directly through CD40 stimulation on Müller cells and indirectly through ATP release by Müller cells,leadingtostimulationofP2X 2021-01-19 Diabetic retinopathy (DR) is a chronic, low-grade inflammatory disease.

This is a condition in which your body doesn't produce or use adequate amounts insulin to function properly. It can be a debilitating and devastating disease, but knowledge is incredible medi Diabetes impacts the lives of more than 34 million Americans, which adds up to more than 10% of the population. When you consider the magnitude of that number, it’s easy to understand why everyone needs to be aware of the signs of the disea Diabetes is the number one cause of reversible vision loss in American adults.
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It results from a lack of, or insufficiency of, the hormone insulin which is produced by the pancreas. There are two types Do you or someone you know suffer from diabetes?

Cell Death Dis 8(5):e2777. doi: 10.1038/cddis.2017.190. Nine clinical trials examining the stem cell-based treatment of diabetic retinopathy were registered on ClinicalTrials.gov, which primarily focused on endothelial progenitor cells (NCT01927315), induced pluripotent stem cells (NCT03403699), hematopoietic stem cells (NCT01972438), embryonic stem cells (NCT02749734 and NCT03046407), autologous CD34 + stem cells (NCT03981549), and autologous bone Diabetes mellitus (commonly referred to as diabetes) is a medical condition that is associated with high blood sugar. It results from a lack of, or insufficiency of, the hormone insulin which is produced by the pancreas.
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av MG till startsidan Sök — En primär cilie är ett orörligt utskott, ett slags antenn på cellytan som samordnar näthinneförändringar (retinal dystrofi) inkluderande retinitis pigmentosa Personer med Bardet-Biedls syndrom får ofta diabetes typ 2 och högt blodtryck. Laurier V, Stoetzel C, Muller J, Thibault C, Corbani S, Jalkh N et al.

4 DIABETIC RETINOPATHY FIGURE 1. Anatomy of the eye. Muller cells and astrocytes are the two key glial cell types found in the retina,¨ and they function as the metabolic modulators for neural and vascular compo-nents of the retina (Abbott NJ, 1992). Both cell types regulate ion concentrations, neurotransmitters, and nutrients for neural cells.

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Diabetic retinopathy (DR) is a chronic, low-grade inflammatory disease. We aimed to investigate the regulatory effects of erythropoietin (EPO) on the inflammatory cytokine production by Muller cells under the condition of DR. The expression levels of TNF-alpha, IL-1beta, IL-6 and VEGF in cultured rat Muller cells were enhanced by 1 mM glyoxal.

We studied the structure and ultrastructure of Muller cells in the retina of thirty 3-month old Wistar rats; divided equally into 3 groups: normal rats, alloxan diabetic rats and treated alloxan diabetic rats. 1 and 12 months after induction of diabetes. Diabetic retinopathy (DR) is a chronic, low-grade inflammatory disease. We aimed to investigate the regulatory effects of erythropoietin (EPO) on the inflammatory cytokine production by Muller the course of diabetic retinopathy, the function of the glu-tamate transporter in retinal Müller cells is compromised by a mechanism involving oxidation. To achieve this aim, this study was designed to quantify GLAST activity in Müller cells that were freshly isolated from normal rats and those made diabetic by injection of streptozotocin. Diabetic retinopathy (DR) is a sight-threatening complication associated with the highly prevalent diabetes disorder. Both the microvascular damage and neurodegeneration detected in the retina caused by chronic hyperglycemia have brought special attention to Müller cells, the major macroglia of the retina that are responsible for retinal homeostasis.